The MBD Check algorithm is a validated diagnostic instrument to screen for a mild bleeding disorder in individual patients.

Supervised machine-learning algorithms model the complex interactions between clinical characteristics and laboratory test results and classify patients accordingly.

The algorithm was derived and intensively validated in two prospective multicenter cohort studies (n=1’393). Expert opinion based on laboratory findings served as the reference standard.

The performance of the algorithm was tested in an external validation dataset. The area under the ROC-curve was 0.86 (95% CI: 0.81, 0.91). Compared to the ISTH bleeding assessment tool the number of patients that were missed was reduced by 92.1 %.

The MBD Check screening algorithm was validated in patients from a cohort that was referred to a hematology outpatient unit. Diagnostic accuracy might change when used in other populations.

The MBD Check algorithm is a non-commercial research tool that has been developed by the PCD research group at Inselspital, University Hospital, and the University of Bern. Scientific societies do not yet support the application of the tool. The algorithm has not been registered as a medical device with the European Medicines Agency (EMA), and it is not CE marked. The application of the algorithm does not replace the standard diagnostic workup in patients with suspected MBD. No patient data is stored with this web-based tool.

Results

Interpretation